Acute colonic pseudo-obstruction caused by mycophenolate mofetil in a kidney transplant recipient.

Mycophenolate mofetil toxicity mimicking acute cellular rejection in a small intestinal transplant

Mycophenolate mofetil (MMF) is an important medication used for maintenance immunosuppression in solid organ transplants. A common gastrointestinal (GI) side effect of MMF is enterocolitis, which has been associated with multiple histological features. There is little data in the literature describing the histological effects of MMF in small intestinal transplant (SIT) recipients. We present a ...

Mycophenolate mofetil-related pancolitis in a kidney transplant recipient.

Gastrointestinal adverse effects are common with mycophenolate mofetil administration, especially diarrhea. We report a case of mycophenolate mofetil-related colitis in a kidney transplant recipient. Colonoscopy revealed an ulcerative diffuse colitis. The colonoscopic biopsy specimen showed mild crypt distortion, accompanied by cryptitis and focal graft-versus-host disease like changes. The pa...

Severe Pneumocystis pneumonia in a renal transplant recipient after long term mycophenolate mofetil treatment.

Sirolimus tolerability in a kidney transplant recipient with acute intermittent porphyria.

Sir, Acute intermittent porphyria (AIP) is transmitted as autosomal dominant disorder with incomplete penetrance. It results from a deficiency of the porphobilinogen deaminase enzyme of haeme biosynthesis. Clinical manifestations of acute attacks include abdominal pain, hypertension and neuro-psychiatric dysfunction, and are often triggered by exposure to exogenous precipitating factors, such a...

Acute abdominal pain and chills in an ADPKD transplant recipient

A 61-year-old female kidney transplant recipient presented with acute abdominal pain and chills. She was diagnosed with autosomal dominant polycystic kidney disease (ADPKD) at the age of 35 and had suffered from several renal cyst haemorrhages. She had been successfully transplanted with a kidney from a deceased donor 1 month earlier, after spending 5 months on haemodialysis; a right nephrectom...